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Thyroid peroxidase antibodies are found in about 6% to 7% of adults, and their prevalence increases with age. Even in asymptomatic individuals, the presence of thyroid peroxidase antibodies can be predictive of hypothyroidism. In addition, thyroid peroxidase testing is thought to be a cost-effective screening method for postpartum thyroid dysfunction
Combined with the test for thyroglobulin antibodies, the presence of thyroid peroxidase antibodies can detect most autoimmune thyroid conditions. This combined testing for autoantibodies can detect almost all goitrous thyroiditis (Hashimoto’sdisease), almost all atrophic thyroiditis (myxedema), and about 70% to 90% of cases of Graves’ disease.